NIH R01 · 2025
The novel role of MIF-CD74 inflammatory pathway in immune regulation
Inflammation negatively affects Tregs stability and suppressive function, impairs the induction of solid organ transplant tolerance and enhances acute and chronic rejection, leading to worse recipients’ long-term outcomes. Insights into key inflammatory pathways that suppress Tregs during allo-immune activation can revolutionize our therapeutic approach to promoting stable endogenous Tregs. Our work strongly suggests that an inflammatory cytokine, macrophage migration inhibitory factor (MIF), secreted by myeloid cells and alloreactive T cells during rejection and inflammation binds CD74 (MIF receptor) on the surface of activated Tregs to dampen its function and homeostasis with opposite…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.