NIH R01 · 2025
Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis
PROJECT SUMMRAY Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus partially mediated by epithelial barrier breach, resulting in harmless antigens penetrating the underlying tissues, encountering immune cells, and triggering allergic responses. The surge in allergy prevalence is often attributed to shifts in environmental conditions and western life style. The molecular mechanisms involved in how the environment elicits allergic diseases is an area of active research that is yet to be fully understood. The aryl hydrocarbon receptor (AHR) is an intracellular receptor responsive to various external stimuli, including dietary compounds, air toxicants, pharmacologic agents,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.