NIH R01 · 2025
Functional dissection of cerebellar output circuits that orchestrate limb motor control
Project Summary The cerebellum is essential for coordinating motor behavior through rapid adjustments of ongoing movements. To refine movement, the cerebellum processes motor and sensory information, and transmits output that ultimately modulates motor neuron activity to ensure successful execution. The path through which the cerebellum can influence limb movement is through output circuits in the cerebellar nuclei (CN). Yet little is known about how CN circuits are organized and whether discrete pathways are dedicated to specific motor functions for limb control. The recent identification of a molecularly distinct subset of CN neurons that project to the cerebral cortex via the thalamus…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.