Azeloglu Lab

Research focus

NIH R01 · 2025

Mechanosensitive determinants of podocyte physiology

PROJECT SUMMARY Drug nephrotoxicity is often conflated with tubular injury; however, many nephrotoxic agents target the glomerulus leading to proteinuric kidney disease. Mechanisms of drug-induced glomerular dysfunction are not well understood. We have previously shown that altered cytoskeletal integrity of podocytes leads to changes in their resilience making them vulnerable to nephrotoxic agents that impact the cytoskeleton. Using meta- analyses to analyze reported renal adverse events of FDA-approved drugs, we identified a previously unknown mechanism of protein kinase inhibitor toxicity that targets actin biophysics. In this project, we utilize this link between regulatory kinase…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.