NIH R01 · 2024
Tolerance defenses in host-microbiota interactions
Project Summary The overall goal of this proposal is to understand how host metabolic adaptations during infection promote co- operative defenses between a host and enteric pathogens to drive asymptomatic carriage and the eventual evolution of commensalism. The proposed studies utilize a natural in vivo host-pathogen involving a enteric bacterial pathogen that causes infectious colitis. In previous work, the Ayres lab discovered that host micronutrient metabolic adaptations during infection with enteric pathogens, regulates host carbohydrate metabolism leading to a phenomenon the Ayres lab calls “metabolic bribery”. This involves the allocation of carbohydrates to the niche of the pathogen…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.