NIH R01 · 2024
Role of oligomeric TDP-43 aggregate intermediates in ALS and frontotemporal dementia
The goal of this grant is to elucidate key mechanisms of TDP-43 aggregation by uncovering how this process leads to pathology and neurotoxicity. TDP-43 aggregation is the pathological hallmark of amyotrophic lateral sclerosis (ALS) and half of frontotemporal dementia (FTD) cases. In addition, TDP-43 lesions are a secondary pathology in approximately 50% of Alzheimer's disease. A major goal in combatting ALS and FTD has been to reduce the accumulation of TDP-43 inclusions by developing strategies to prevent or reverse TDP-43 aggregation. Recognizing this, we established strategic methods to study the aggregation of this RNA binding protein using purified TDP-43 and have identified previously…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.