NIH R01 · 2025
Effects of tobacco smoking on prognosis and immune function in multiple sclerosis
PROJECT SUMMARY Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous system (CNS) inflammation and neuronal demyelination. Despite therapeutic advancements, the clinical heterogeneity among MS patients presents challenges in accurately predicting and monitoring disease progression. While previous studies have linked poor prognosis in MS patients to elevated TH17 and B cell activities, the underlying reasons for the activation of these pathways remain unclear. In our exploratory proteomic study focused on relapsing-remitting MS (RRMS) patients, we discovered that correlation between poor prognosis and heightened TH17 and B cell activation pathways is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.