NIH R01 · 2024
A multidisciplinary approach to understanding feedback and clustering in PCP signaling
Summary/Abstract Planar cell polarity (PCP) signaling controls the polarization of cells within the plane of an epithelium, orienting asymmetric cellular structures, cell divisions, and cell migration and is well conserved from Drosophila to vertebrates. In vertebrates, defects in the core PCP mechanism result in a range of developmental anomalies and diseases including conotruncal heart defects, open neural tube defects, deafness, and situs inversus and heterotaxy, among others. Congenital heart disease (CHD) comprises close to half of all birth defects, and conotruncal heart malformations are the most common CHDs in humans, and include anomalies such as double outlet right ventricle,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.