NIH R01 · 2024
Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH) PROJECT SUMMARY Cerebral cavernous angioma (CA) is a capillary microangiopathy affecting more than a million Americans, predisposing them to a premature risk of brain hemorrhage. Fewer than 200,000 cases who have suffered a recent symptomatic hemorrhage (SH) are most likely to re-bleed again with serious clinical sequelae, and are the primary focus of therapeutic development. Genetic mechanisms of CA have been extensively studied, and consequent signaling aberrations in the neurovascular unit. These include proliferative dysangiogenesis, blood- brain barrier hyperpermeability, inflammation and immune mediated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.