NIH R01 · 2025
Program control of CD8+ T cell response to tumors and tumor memory
Abstract CD8+ tumor infiltrating lymphocytes (TILs) are not only critical for the anti-tumor immune response in solid tumors, but also in the success of adoptive cell therapies and in immune check point blockade (ICB) treatments. CD8+ TILs have been shown to be heterogeneous, and in time to progress to a terminally exhausted state, with no ability to respond, and resistant to reprograming by ICB. It remains of critical importance to understand the biology, transcriptional programs and epigenetic control of the progression of the precursors, which have high functional potential and stemness, to the terminally exhausted CD8+ TILs. Cells with characteristics of memory have been identified in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.