NIH R01 · 2024
Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII Pathway
Project Summary/Abstract Most pathogenic bacteria express surface carbohydrates called capsular polysaccharides (CPSs). CPSs are important vaccine candidates given that they are located on the outermost surface of bacteria and have distinct structures. These two features make them easily accessible and distinctly recognizable by immune surveillance, therefore resulting in the production of CPS-specific antibodies by B cells. To induce a CPS- specific adaptive immune response (i.e., T cell-mediated B cell response), CPSs are conjugated with carrier proteins, and the conjugation products are called glycoconjugate vaccines. Due to insufficient understanding of their immune activation…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.