Autry Lab

Albert Einstein College of Medicine

NONE

Bronx · United States

NIH-funded
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NIH R01 · 2025

Circuit, cellular, and molecular plasticity in hypothalamic microcircuits underlying flexible infant-directed behavior

ABSTRACT Human parents and non-parents show sharply distinct patterns of brain activity in response to infant cries or laughter. How is this change in brain responses accomplished? Receiving parental care is essential for appropriate physical, cognitive, and emotional development in infants. Failure to care for an infant predisposes the individual to neurodevelopmental and psychiatric disorders. Caregiving behavior is mediated by neural circuits that promote bonding with infants. Past research has primarily focused on neural mechanisms in mothers associated with pregnancy, parturition, and lactation that facilitate parenting. However, many species show bi-parental care, suggesting that…

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