NIH R01 · 2024
The Variation of the NK Cell Receptome in Pemphigus
ABSTRACT Pemphigus is a broad term denoting a subset of potentially life-threatening autoimmune blistering skin diseases with a prevalence of 5.2 cases per 100,000 adults in the United States. Several genetic variants strongly increase PF risk, including variants within the major histocompatibility complex (MHC), such as the human leukocyte antigen (HLA) class I and II genes. The PI has contributed significantly to uncovering susceptibility genetic variants in PF, including a recent genome-wide association study. Remarkably, variants in genes encoding natural NK receptors have been strongly associated with PF susceptibility, and some of these associations were explained by differential…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.