NIH R01 · 2024
Allosteric Modulators of Dopamine Transporter as Therapeutic Agents for NeuroAIDS
PROJECT SUMMARY Although acute viral replication has been well controlled with combination antiretroviral therapies (cART) in the early stage of HIV infection long-term HIV-1 viral protein exposure within the CNS causes dysregulation of monoamine transmission, which has been implicated as a key factor in HIV associated neurocognitive and depression-like behavior deficits with concurrent cocaine abuse. Cocaine abuse has been shown to enhance the incidence of HIV-1 associated cognitive depression and exacerbate its severity. Dopamine (DA) plays a significant role in the prefrontal cortex, which is an important brain region for higher cognitive function. Both DA transporter (DAT) and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.