NIH R01 · 2024
Identifying Convergent Circuit Disruptions Across Genetically-Distinct Models of Autism
Identifying Convergent Circuit Disruptions Across Genetically-Distinct Rat Models of ASD Summary: Recent advances from human genetic and animal studies have greatly increased our understanding of the molecular and cellular basis of autism spectrum disorders (ASD). Connecting these risk factors to clinical symptoms in autism remains a significant challenge that has impeded the development of ASD therapies, as evidenced by disappointing results from recent large-scale clinical trials. A fundamental question is if distinct ASD mutations converge on shared disease mechanisms at some level of neuronal function to ultimately give rise to the behavioral and neurocognitive phenotypes that define…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.