NIH R01 · 2024
Studying the Molecular Regulation of MGE Projection Neuron Identity by St18
PROJECT SUMMARY: The medial ganglionic eminence (MGE) is a neural progenitor domain located in the ventral telencephalon. It is well-studied for its production of cortical interneurons, a broadly distributed population of locally-pro- jecting neurons that regulate cortical rhythmicity. The MGE also produces projection neurons that remain in the ventral forebrain, arranged in discrete nuclei that project distally point-to-point. Interneuron and projection neuron identity represent two fundamentally-distinct populations, with distinct functions. How the MGE delineates between the production of IN and PN, however, is not understood. We have identified a transcription factor, St18 that appears…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.