Atwood Lab

University of Minnesota

PHARMACOLOGY

Minneapolis · United States

NIH-funded
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NIH R01 · 2025

Impact of prenatal opioid exposure on corticostriatal circuits that modulate alcohol-related behaviors

Project Summary The number of children born to opioid-dependent mothers has increased over 300% in the past two decades. As abstinence from opioids during pregnancy is not recommended, opioid medication replacement therapy, such as methadone, represents the standard of care for pregnant women with opioid use disorder thus perpetuating the birth of these opioid-exposed babies. Previous work has shown that prenatal opioid exposure predisposes for future substance misuse. Given its widespread accessibility, alcohol is one of the most likely addictive sub- stances that these prenatal opioid-exposed children will encounter. Due to the significant morbidity and mortality associated with excessive…

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