NIH R01 · 2024
ABSTRACT Sickle cell disease (SCD) is characterized by a vasculopathy affecting multiple end organs, with complications including chronic kidney disease (CKD). Albuminuria, an early measure of glomerular injury, is common in SCD and predicts progressive kidney disease. Kidney function decline is faster in SCD patients than in the general African American population. The prevalence of rapid decline in SCD is 3-fold higher than in the general population. Furthermore, high-risk APOL1 variants are associated with an increased risk of albuminuria and progression of CKD in SCD. Kidney disease, regardless of severity, and rapid eGFR decline are associated with increased mortality in SCD. As such,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.