Atabai Lab

Research focus

NIH R01 · 2025

Integrin regulation of insulin sensitivity

SUMMARY Insulin resistance is a major risk factor for cardiovascular disease which in turn is the major cause of morbidity and mortality in diabetes. The prevalence of insulin resistance is increasing in the setting of a global obesity epidemic. The long-term goal is to understand the role of the integrin family of cell surface matrix receptors in regulating obesity and insulin resistance. The overall objective of this application is to elucidate the role of the αvβ5 integrin and its ligand, Milk Fat Globule Epidermal Growth Factor like 8 (Mfge8), in regulating skeletal muscle insulin resistance. The central hypothesis is that insulin accelerates movement of MFGE8 through the endoplasmic…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.