NIH R01 · 2024
Summary/Abstract: Initial cocaine abstinence is associated with severe sleep disturbances. Poor sleep is one of the strongest predictors of return to use (relapse), suggesting potential overlap in brain arousal and reward networks. Separate literatures link orexin (hypocretin) neurons in lateral hypothalamus (LH) to the regulation of wake and drug motivation, yet how these neurons might commonly contribute to sleep disturbances and subsequent drug use in CUD is not well understood. In rats, the intermittent access (IntA) schedule of cocaine self-administration increases cocaine demand, a behavioral economics measure of drug motivation. These motivational changes are persistent and are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.