NIH R01 · 2025
Phage Therapy for Recurrent UTIs in Kidney Transplant Recipients
PROJECT SUMMARY/ ABSTRACT Recurrent urinary tract infections (rUTI) are a common problem in kidney transplant recipients (KTR), especially women, and lead to serious consequences – pyelonephritis, bacteremia, kidney dysfunction, and death. Escherichia coli and Klebsiella pneumoniae are usually implicated. Antibiotics are associated with adverse events, increased multi-drug resistance; and they do not prevent a future recurrent UTI (rUTI) due to microbiome persistence of the uropathogen. New strategies to combat rUTI are critically needed. Bacteriophage (phage) therapy consists of administration of viruses that specifically bind to target bacteria leading to an intracellular replicative…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.