NIH R01 · 2025
Regulation of learning and memory by steroid hormone signaling during development and aging
PROJECT SUMMARY/ABSTRACT There is currently a paucity of therapeutic approaches for ameliorating cognitive declines that characterize neurodegeneration and aging. We have been investigating kynurenic acid, KYNA, a tryptophan derived metabolite, as a nexus in metabolism, aging, and learning and memory in C. elegans. There is compelling evidence from multiple species including C. elegans and mice that reductions in KYNA improve learning and memory while increases in this neuromodulatory metabolite have detrimental effects. In both C. elegans and mice KYNA accumulates with age. KYNA accumulation also characterizes several forms of human neurodegeneration. We previously demonstrated that KYNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.