NIH R01 · 2025
As the average age of the population increases, understanding the biology of longevity and diseases of aging is increasingly important. The key role of mitochondria in Alzheimer’s disease (AD) and pathogenic aging has been established in studies across species and mechanistically validated using genetically engineered models. Mitochondrial DNA copy number (mtDNAcn) changes with age and diet, in various tissues, and across species. Higher mtDNAcn is associated with better health outcomes in aging and with increased longevity, while decreased mtDNAcn is linked to disorders of aging including AD. However, we do not understand the mechanistic interaction between genetic variants, mtDNAcn, diet,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.