NIH R01 · 2024
Mechanisms of Impaired Inflammation Resolution in Cystic Fibrosis Lung Disease
Patients with cystic fibrosis (CF) suffer from chronic infections and lung inflammation leading to bronchiectasis and, ultimately, respiratory failure. Although recent advances, including the approval of highly effective CFTR modulator therapy (HEMT), have improved the overall quality of life of people with CF (PwCF), chronic infection and inflammation are the primary cause of morbidity. Although the magnitude of the inflammatory response is known to be increased in the CF lung, the mechanisms underlying persistent inflammation are unknown. We have shown that lung macrophages are critical to the local inflammatory response in CF. Lung macrophages include functionally distinct subpopulations…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.