NIH R01 · 2025
Mechanisms of Methylmercury Induced Neuronal Toxicity
PROJECT SUMMARY Methylmercury (MeHg) is a potent neurotoxin affecting both the developing and mature central nervous system with apparent indiscriminate disruption of multiple homeostatic pathways. However, genetic and environmental modifiers contribute significant variability to neurotoxicity associated with human exposures. Furthermore, neurotoxic outcomes show evidence of persistence and latent effects long after exposure has subsided. MeHg neurotoxicity is associated with oxidative stress and impaired redox homeostasis, mitochondrial dysfunction, activation of cell stress pathways, alteration of proteostasis, calcium dysregulation, damage to neuronal processes and neuronal/synaptic…
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