NIH R01 · 2024
Microbiota-mediated fibrotic remodeling in the inflamed intestine
ABSTRACT Fibrotic disorders are associated with an estimated 45% of human deaths. Chronic inflammation-associated intestinal fibrosis is a significant complication in ~40% of Crohn’s disease (CD) patients. This condition causes severe intestinal thickening and blockage, and is the most common reason for bowel resection in CD patients. Despite this public health problem, there is minimal understanding behind the disease process of CD- associated fibrogenesis. The microbiota provides a putative causal link to CD and other inflammatory bowel diseases, but it remains unknown which specific microbial products induce distinct cellular responses and host phenotypes. We hypothesize that a class of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.