Arteel Lab

Research focus

NIH R01 · 2024

Novel Biomarkers for Post-Liver Transplant NASH Fibrosis

Our overarching goal is to develop minimally invasive approaches to better predict outcome and novel mechanisms in post-liver transplant (LT) NASH fibrosis. Although LT is an effective therapy for NAFLD cirrhosis, the risk of post-transplant NAFLD is alarmingly high, particularly for recurrent non-alcoholic steatohepatitis (NASH) with an incidence of up to 70% at 5 years. Effective approaches to predict risk hamper the treatment and prevention of post-LT NASH fibrosis. The hepatic extracellular matrix (ECM) responds dynamically to organ injury and ECM turnover increases; we propose to take advantage of this to develop new biomarkers for post- LT NASH fibrosis. The peptidome, low molecular…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.