NIH R01 · 2024
Mechanisms of photoreceptor disc maturation
The experiments described in this proposal address one of the most fascinating unanswered questions in vision research regarding the molecular mechanisms responsible for photoreceptor outer segment morphogenesis. The outer segment is a ciliary organelle that produces electrical signals in response to capturing light. A unique morphological feature of the outer segment is that it is filled with a stack of flattened membrane discs providing vast surfaces for photon capture and signal amplification. The functional significance of this anatomical arrangement has been recognized for a very long time, yet our understanding of how discs are built at the molecular level remains frustratingly…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.