NIH R01 · 2024
The role of hepatic Endoplasmic Reticulum architecture in metabolic homeostasis and disease
ABSTRACT: Metabolic dysfunction Associated Fatty Liver Disease (MAFLD) is the most common chronic liver disease, yet treatment options are limited. Within hepatocytes, the endoplasmic reticulum (ER) serves as a crucial hub for protein and lipid metabolism. Substantial evidence shows that dysfunction of hepatic ER, characterized by loss of its adaptive capacity, is a key mechanism involved in metabolic deterioration in MAFLD. However, the exact mechanisms underlying ER dysfunction in this condition are unknown. Recently, work from our lab has revealed a new angle: obesity leads to a marked loss of hepatic ER architectural organization, which significantly impacts its function. Moreover,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.