NIH R01 · 2025
Beta cell adaptation mechanisms during caloric restriction and ER stress
Project Summary Type 2 diabetes (T2D) is caused by the collapse of glucose homeostasis mechanisms, and the odds of devel- oping T2D increase during old age. Beta cells make insulin, a major hormone involved in the regulation of glucose homeostasis; these cells modulate insulin release in response to changes in blood glucose levels and/or meta- bolic demands. During T2D and aging, beta cell function and identity become compromised due to activation of stress pathways. Recent studies by us and others show that aging beta cells experience an underlying state of chronic endoplasmic reticulum (ER) stress associated with compromised autophagic flux and reduced expres- sion of beta cell identity…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.