NIH R01 · 2024
Neuronal Circuit Controlling Sleep-Promoting Ventrolateral Preoptic Neurons
Project Summary/Abstract Sleep is an active process requiring the participation of delimited nodes of sleep-promoting cell populations. Work over the last twenty years has demonstrated that galanin expressing neurons in the ventrolateral preoptic (VLPOGal) neurons are necessary for normal sleep and cortical slow wave activity. There remain however several fundamental gaps in our understanding of the cellular and synaptic basis by which VLPOGal neurons are regulated. One highly influential circuit model for behavioral sleep-wake control is the `flip-flop' model of sleep-state switching, which proposes that sleep-wake transitions are regulated by a reciprocal inhibition between…
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