NIH R01 · 2025
Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods
Summary Different cell types, each with unique composition, properties, and functions, are essential to sustain life in an organism. Bulk analysis of such heterogeneous mixtures of cells does not distinguish the characteristics of a given cell type or differences between cells within the same type, missing information that is key to understanding molecular mechanisms foundational to the rational design of therapies for disease and ailments. The goal of this proposal is to develop single-cell and imaging methods using metal-bearing probes to monitor metabolic processes in live cells such as siRNA delivery, protein synthesis, and post-translational modification. The cells will then be fixed…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.