Aromolaran Lab

Research focus

NIH R01 · 2025

Channelopathies of Inflammation

PROJECT ABSTRACT Obesity is associated with a higher risk for the development of malignant ventricular tachyarrhythmias (VT), particularly under conditions of repolarization disorders and QT interval prolonging mechanisms (an established risk factor for VT), and sometimes tragically transitions to sudden cardiac death. In obesity, excess dietary fat in adipose tissues stimulates the release of immunomodulatory cytokines such as interleukin(IL)-6, leading to a state of chronic inflammation in patients. In the past decade, IL-6 trans-signaling has emerged as a powerful predictor of risk for VT. The first selective inhibitor of IL-6, olamkicept, has shown encouraging results in phase II…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.