NIH R01 · 2024
B. thuringiensis crystal proteins as powerful next-generation anthelmintics
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms, roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and working adults. Mass drug administration with albendazole has not been curative, and there are limitations with additional approaches involving ivermectin and the experiment drug emodepside. Controlling GINs remains a critical unmet medical need. For over 60 years, Bacillus thuringiensis crystal (Cry) proteins have been safely and massively used to combat insect pests that vector disease and damage crops. Pioneering work has shown that some Cry proteins (e.g., Cry5Ba) target…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.