NIH R01 · 2025
Methods for anterograde tracing of active circuits
Project Summary A central yet unrealized goal of modern neuroscience is to map all the neural circuits within the brain and the changes that occur during development, learning, aging, and in disease states. Towards this end, we recently developed a rationally designed method for anterograde transsynaptic tracing from excitatory presynaptic neurons that is monosynaptic, activity-dependent, and non-toxic and provides genetic access to postsynaptic cells. This rational approach has many advantages over traditional methods based on viruses' intrinsic transsynaptic labeling capabilities. We have shown that in our method, the tracer is released presynaptically and binds to a postsynaptic protein…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.