NIH R01 · 2024
Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
PROJECT SUMMARY Obesity is a global epidemic that is associated with sympathetic overactivation, endothelial dysfunction, and insulin resistance; all of which can contribute to hypertension development. Despite well-established clinical associations, the mechanisms connecting obesity with hypertension remain poorly understood, with several antihypertensive therapies eliciting detrimental metabolic effects. This illustrates the need to identify new targets with a positive metabolic profile for treatment of obesity hypertension. We propose that angiotensin-(1- 7), a protective hormone of the renin-angiotensin system, provides this ideal target. In support of this concept, we have shown that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.