NIH R01 · 2024
Structure and Function of Integrins in the Kidney
Abstract The stoichiometric cis association of the tetraspanin CD151 with podocyte integrin α3β1 is essential for stabilizing α3β1 in an active ligand-binding conformation, thus maintaining the integrity of the glomerular filtration barrier (GFB). Other studies also show that activation of αvβ3 in podocytes by inflammatory mediators, growth factors or mechanical/shear stress plays a critical role in disrupting the GFB. Taken together, these data suggest that α3β1 and αvβ3 play opposing roles in regulating GFB homeostasis, but the biochemical and structural basis of this functional antagonism in disease is unknown and how the glomerulus responds to injury in the complete absence or…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.