Armbruster Lab

Research focus

NIH R01 · 2024

The urothelial glycosaminoglycan layer: composition and contribution to pathogen fitness during catheter-associated urinary tract infection

Project Summary/Abstract Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a particularly high risk of UTI sequelae, including kidney infection, permanent renal damage, and urosepsis. The average mortality rate for urosepsis is 20-40%, but ranges as high as 66% for patients with catheter- associated UTI (CAUTI). Catheterization also promotes polymicrobial colonization and infection by a wide range of understudied microbes, including multidrug-resistant organisms that threaten the utility of last- resort antibiotics, and there is a…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.