NIH R01 · 2025
Human Mitochondrial Variation and Sudden Cardiac Arrest Risk and Resuscitation
Sudden cardiac arrest (SCA) is a major public health concern, accounting for up to 400,000 deaths each year. While SCA cases are heterogeneous in etiology, the most common underlying pathologic substrate is ischemic heart disease and the most common electrophysiologic mechanism is ventricular fibrillation (VF). Survival following VF-SCA is less than 20% in most communities with mortality due largely to fulminant injury of either the heart or brain. Accordingly, there is a compelling case to identify novel modifiable SCA risk factors, to elucidate its underlying pathophysiology, and to identify novel preventative and therapeutic targets. The mitochondrion has primary function in energetics,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.