NIH R01 · 2024
Galectin-3 and corneal nerve regeneration
Project Summary/Abstract The avascular cornea is innervated by a dense network of sensory processes derived from the ophthalmic and maxillary regions of the trigeminal ganglion. Corneal nerves provide not only mechanical, chemical, and thermal sensitivity to the front of the eye but also release nutrients and trophic factors that supply the cornea. Structural and functional nerve abnormalities are the hallmarks of neurotrophic keratopathy, a degenerative disease associated with impaired corneal healing and ulceration. These abnormatilies can also be observed in other conditions known to cause corneal damage, such as dry eye. Most therapeutic approaches aimed to promote corneal nerve…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.