NIH R01 · 2025
Naive CD8 T cell functional heterogeneity
Project Summary There has been considerable progress in identifying subsets in effector, memory, and exhausted CD8 T cells, and our understanding of the role of each subset in response to infection has greatly improved. However, much less is known about the heterogeneity of naïve CD8 T cells, the predecessors of these antigen-experienced T cells. We have recently tackled this important issue, and our preliminary data show that there is a naïve CD8 T cell population with a superior ability to generate more effector CD8 T cells after infection. A deeper understanding of the naïve CD8 T cell heterogeneity will help to develop strategies to produce just such a better naïve CD8 T cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.