NIH R01 · 2025
How NTS NPY neurons alter NTS circuitry to promote food intake
Obesity is a major health problem in the United States and a leading contributor to cardiovascular disease, diabetes mellitus and stroke. One region essential for the control of meal size is the nucleus of the solitary tract (NTS) in the brainstem. Vagal afferent fibers carrying different types of satiety information from the GI terminate in the NTS, and NTS neurons process this information before relaying it on to other brain regions to terminate a meal. Activation of NTS neurons therefore critically impacts meal length. However, NTS neurons are extremely heterogeneous in their expression of peptides and receptors. Activation of most NTS neuronal populations inhibits FI, including general…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.