NIH R01 · 2024
The role of cortical long-range GABAergic inhibition on emotional learning
PROJECT SUMMARY/ABSTRACT Proper emotional responses are characterized by the dynamic interplay of two major forces: excitation and inhibition. A current belief is that dysfunction of inhibition, mediated by local GABAergic interneurons, leads to a wide range of psychopathologies including phobias and anxiety disorders. A well-established principle of the circuit organization underlying emotional learning is that inhibition is local while excitation is both local and long- range. Specifically, a considerable amount of research on cortico-amygdala communication (coordination of sensory input between the auditory cortex and the lateral amygdala) relies on the reductionist view that the…
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