Anwar Lab

Research focus

NIH R01 · 2024

Chip-Scale Intraoperative Optical Navigation with Immunotargeted Upconverting Nanoparticles

Project Summary/Abstract Residual cancer cells left behind following surgery increase the chance of cancer returning in almost every cancer subtype. The current inability to identify these tumor cells during surgery hinders cancer care across the spectrum, including breast and prostate cancers, as 20-40% of these patients suffer from positive margins, which doubles the risk of cancer returning. This proposal solves this problem through an original approach for ultrasensitive optical imaging of cancer cells in live tissue and during surgery. Current intraoperative imaging methods are unable to achieve high sensitivity both on the tissue surface and at depth due to inherent physical limits of…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.