Antonson Lab

University of Illinois at Urbana-Champaign

VETERINARY SCIENCES

Champaign · United States

NIH-funded
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NIH R01 · 2025

Investigating Transplacental Immune Pathways Contributing to Fetal Brain Pathology in Maternal Influenza

Project Summary/Abstract The overarching goal of this application is to identify targetable transplacental immune signaling pathways for optimizing antenatal therapies that improve maternal and offspring health outcomes during seasonal influenza outbreaks. Influenza viruses pose ever-present threats to the health of pregnant women and escalate the risk of neurodevelopmental disorders in their offspring. Yet, how and which immune signals propagate across the maternal-fetal interface to impact fetal brain development during gestational influenza virus infection are unknown. The objective of this proposal is to assess the extent to which transplacental immune signaling drives fetal brain…

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