NIH R01 · 2024
Multiscale Model of Thrombosis in Artificial Circulation
ALL blood-wetted devices, without exaggeration, are susceptible to unintended thrombosis and bleeding – with dire consequences. In spite of decades of clinical experience, basic research, and computational fluid dynamics modeling, it is still virtually impossible to avoid deleterious hematological effects without anticoagulation, or experimental trail-and-error. The unfortunate consequence is an unacceptable rate of debilitating adverse events such as stroke and hemorrhage. This abiding challenge has driven the PIs over the past 25+ years to pursue a deterministic, multi-scale, multi-constituent, convection-diffusion-reaction model of thrombosis that embraces the principle elements of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.