Ansel Lab

Research focus

NIH R01 · 2025

MicroRNA directed pathway discovery in allergy and asthma

PROJECT SUMMARY Asthma is a highly prevalent chronic inflammatory airway disease that is genetically and mechanistically linked to allergy and dysregulated cytokine-mediated communication between the airway epithelial barrier and tissue-infiltrating immune cells. Th2 responses, insufficiently checked by Tregs, drive chronic allergic inflammation through the release of cytokines that signal through STAT6. Discovering novel regulatory circuits that control this process is a research opportunity with high promise for therapeutic application. In the proposed research, we will investigate RNA circuits that regulate Treg function and the pathobiology of allergy and asthma. Strong preliminary data…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.