NIH R01 · 2025
Project Summary Regulated transcription of genes is essential for cell proliferation, differentiation and viability. Any misregulation may lead to a disease or a developmental abnormality. The transcription cycle of eukaryotic genes consists of multiple steps. The accomplishment of each of these steps requires a number of accessory factors. The initiation of transcription by RNAPII requires gene-specific factors and the general transcription factors (GTFs). The conventional view is that the general transcription factors (GTFs) operate exclusively at the initiation step of transcription. Many recent studies have challenged this dogma. The successful execution of the transcription cycle…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.