NIH R01 · 2025
Gene regulation mechanisms involving the inactive X in B cells during lupus disease
Females are predisposed for developing systemic lupus erythematosus (SLE), but the underlying mechanisms remain obscure. Chronic inflammation is also a feature of SLE, and the majority of SLE patients have elevated type I interferon (IFN) levels and increased expression of interferon signature genes. B cells from female SLE patients exhibit aberrant expression of X-linked immunity-related genes, including TLR7, TASL, IRAK1, TIMP1, and BTK, suggesting that dysregulation of X-linked gene expression may contribute to the female bias of this disease. While Type I IFN has pleiotropic effects on the immune system, it also upregulates TLR7 expression, raising the intriguing possibility that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.