Angelucci Lab

Research focus

NIH R01 · 2025

Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses

In the mammalian sensory cortex, hierarchically-organized areas are reciprocally connected via feedforward (FF) and feedback (FB) circuits. FF connections generate the more complex response properties of neurons in higher areas within parallel streams specialized in processing specific stimulus attributes. In contrast, the function of FB connections remains unknown. In the visual cortex, FB has been implicated in top-down phenomena, such as visual attention, prediction, and visual context. However, these roles have remained hypothetical, due to the lack of tools to selectively label, record, and manipulate the activity of FB neurons. As FB circuits are ubiquitous in cortex, and…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.